Compliance is a game of complexity and frameworks. The relationship between misconduct and organizational culture, for instance, is complex, and that is not including the overlay of industry, local, national and international cultures. A compliance program offers frameworks to create some order and to encourage or discourage certain behaviors. This guest article tackles two complex subjects – compliance and culture – and provide frameworks to help make sense of them. See “The Parallels and Distinctions Between Investigations and Culture Reviews” (May 26, 2022).