Although there are expectations of a lighter regulatory touch under the Trump administration, CCOs must not let down their guards, according to the former senior SEC attorneys and officials at a PLI program on establishing and running an effective compliance program in the current environment. The speakers discussed the need to prioritize and understand the business; credibility and culture; policies and procedures; training; strategies for operating with limited resources; handling SEC staff inquiries; compliance program updates; how artificial intelligence is being incorporated into compliance functions; and the current examination and enforcement climates. This article synthesizes the key takeaways from the program, which was moderated by Osman Nawaz, partner at Gibson, Dunn & Crutcher LLP and former Senior Officer and Chief of the Complex Financial Instruments Unit in the SEC’s Division of Enforcement. See our three-part series on the first 100 days as GC/CCO: “Preparing for the Role and Setting the Tone” (Apr. 29, 2021); “Developing Knowledge and Forging Key Relationships” (May 6, 2021); and “Managing Daily Work, Performing Risk Assessments and Looking Ahead” (May 13, 2021).